4-variable KFRE to predict progression to kidney failure.
The Kidney Failure Risk Equation (KFRE) uses age, sex, eGFR, and urine albumin-to-creatinine ratio (ACR) to predict progression to kidney failure requiring dialysis or transplant. It is validated for CKD stages 3–5 and is recommended by KDIGO guidelines for referral decisions. A 5-year risk ≥ 3–5% often triggers nephrology referral.